Polymerization of chondroitin sulfate and its stimulatory effect on cartilage regeneration; a bioactive material for cartilage regeneration

Chondroitin sulfate (CS) is one of the major glycosaminoglycans (GAGs). GAGs are linear polymers comprising disaccharide residues and found as side chains proteoglycans. CS has significant stimulatory effects on cell behavior widely used in tissue-engineered drug delivery devices. However, it difficult to incorporate a sufficient amount into biopolymer-based scaffolds such collagen take full advantage its benefit. In this study, been polymerized an 11 times higher molecular weight polymer (PCS) attempt overcome deficiency. We have previously shown that PCS was significantly more effective than chondrogenesis. This study aimed characterize physicochemical properties manufactured PCS. characterized by Fourier transform infra-red (FTIR) spectroscopy together with X-ray photoelectron (XPS) obtain information about chemical structure elemental composition. Its size measured using dynamic light scattering (DLS) viscoelastic were determined rheology measurements. The average diameter increased 5 polymerization enhanced compared CS. calculated from rheological experiment give order magnitude increase over weight. Based these results, we believe there great potential for regenerative medicine